Overview, Causes, & Risk Factors
Gestational diabetes is an intolerance to glucose that first occurs, or is
first detected, during pregnancy.
Glucose is the main form of sugar in the body. Gestational diabetes occurs in
4% of all pregnancies.
What is going on in the body?
Glucose is an important source of energy used by the body's cells. When a
person eats, the pancreas normally makes extra insulin. The insulin causes the
glucose in the blood to move inside the body's cells. In a woman with
gestational diabetes, the hormones produced in pregnancy block the effects of insulin. Glucose then builds up
in
the blood and the cells are left without a main source of energy. The result is
a high level of glucose in the blood, a condition known as hyperglycemia. High
blood sugar levels can damage the growth of the fetus. This may cause complications
for both the mother and baby.
What are the causes and risks of the disease?
The following conditions may increase a woman's chance of developing
gestational diabetes:
age over 25 years
family history of diabetes
mellitus, including type 1
diabetes
mellitus or type 2 diabetes
mellitus in a sibling or parent
personal history of gestational diabetes
marked obesity
previous delivery of an infant with a birth weight of more than 9 pounds
a previous stillbirth
previous delivery of a child with birth defects
recurrent or persistent bladder
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glucose in the urine sample taken in the healthcare provider's
office
being a member of an ethnic group with a high incidence of gestational
diabetes. This includes women of Latino, African American, Native American,
Asian, or Pacific Islands descent.
Symptoms & Signs
What are the signs and symptoms of the disease?
Usually there are no symptoms of gestational diabetes. If symptoms develop, they
are often mild and may include:
excessive thirst
excessive weight gain or sometimes excessive
weight loss despite increased appetite
increased urination
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fatigue
nausea
vomiting
blurred vision
recurrent or persistent bladder infections or bacteria in
the urine
Diagnosis & Tests
How is the disease diagnosed?
The American Diabetes Association (ADA) recommends glucose testing of women
with any of the risk factors listed above as soon as feasible during pregnancy.
If gestational diabetes is not diagnosed during the initial screening of high
risk women, they should be retested between 24 and 28 weeks of pregnancy.
Similarly, women of average risk should be tested between 24 and 28 weeks of
pregnancy.
The ADA describes 2 approaches to evaluation of gestational diabetes in
pregnant women:
The one-step approach is done with an
oral glucose tolerance test. The woman drinks a liquid containing 50
grams of glucose and the blood glucose level is measured an hour later.
The two-step approach starts with the same oral glucose tolerance test as the one-step approach. If the
woman's blood glucose is elevated on the first test, a diagnostic oral glucose
tolerance test is done. The woman drinks a liquid containing 100 grams of
glucose, and the blood glucose level is measured 1, 2, and 3 hours later.
If the blood glucose level is elevated in either of the approaches, a
diagnosis of gestational diabetes is made.
Prevention & Expectations
What can be done to prevent the disease?
Gestational diabetes can sometimes be prevented by regular exercise and a
balanced diet to maintain a healthy weight before conceiving and during pregnancy. It is important to let the
healthcare provider know if there is a family history of diabetes.
What are the long-term effects of the disease?
Complications for the mother include:
bacteria in the urine, with chronic
bladder infections
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higher risk of preeclampsia, or very high blood pressure
swelling in the arms and
legs
as a result of fluid buildup
carpal tunnel syndrome, or pain and numbness involving the hand and arm
premature labor
increased need for medication to induce labor
increased risk of forceps delivery or cesarean section
What are the risks to others?
Complications for the baby include:
macrosomia, which means having a large body
polyhydramnios, or excessive amniotic fluid
increased incidence of birth defects
premature delivery
increased risk of
miscarriage
hypoglycemia, or low blood
sugar levels at birth
hypocalcemia, or low calcium levels at birth
polycythemia, or too many red blood cells at birth
respiratory problems, including respiratory distress
syndrome
cardiomyopathy, or damaged heart tissue
congestive heart failure
increased risk of birth trauma such as shoulder dystocia, which occurs
when the baby's shoulder gets stuck during delivery
decreased ability of the baby to tolerate labor
Treatment & Monitoring
What are the treatments for the disease?
The goal of treatment is to bring blood glucose levels to normal, and to keep
them there throughout the pregnancy. This will prevent complications for both
mother and child. The diet should provide enough calories and nutrients to
allow appropriate weight gain in both mother and fetus. A dietician will
provide counseling and education. If changing the diet does not control glucose
levels, insulin injections may be needed.
Until recently, oral medications were not recommended for gestational diabetes.
However, a recent study indicated that glyburide is safe and effective to take
in the last 6 months of pregnancy.
What are the side effects of the treatments?
Hypoglycemia, or low blood sugar, may result if too
much insulin is given, or if meals are skipped. Hypoglycemia should be avoided,
because the fetus will also experience low blood sugar levels.
What happens after treatment for the disease?
Pregnancy hormones drop dramatically after delivery, and a woman may no longer
need insulin. High blood glucose levels usually go away after pregnancy. But 30%
to 40% of women with gestational diabetes may develop type 2 diabetes at some time in their lives. Obesity or a family history of diabetes
may
increase this risk. A balanced diet and exercise after delivery will help with
weight loss and will lower the risk of
diabetes in the future. At the exam 6 weeks after delivery, a oral glucose tolerance test can help
determine
if further treatment is needed.
How is the disease monitored?
Women with gestational diabetes run a high risk of having it in future
pregnancies. Women who previously had gestational diabetes but are not pregnant should
have fasting blood sugar tests
each
year to detect diabetes.